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Background: Elevated plasma homocysteine level is an independent risk factor for cardiovascular disease in women with polycystic ovary syndrome (PCOS). In the presence of methylnetetrahydrofolate reductase (MHTFR) mutation, elevated homocysteine levels are observed. The purpose of this study was to detect the existence of MHTFR polymorphism in patients diagnosed as having PCOS in the reproductive period and to determine whether the levels of serum homocysteine and folate changed in patients with different MHTFR genotypes after the administration of an oral contraceptive agent. Methods: The study included 50 PCOS patients and 50 healthy controls aged between 17 and 35. The patients diagnosed with PCOS were divided randomly into two groups. While the first group of 25 patients was administered 30 µg ethynyl estradiol+150 µg desogestrel the other group of 25 patients was monitored without administering medication. Results: It was found moreover that the MTHFR enzyme led to an increase in the serum homocysteine levels of both the MTHFR and the control group. MTHFR polymorphism was found to be of similar ratios in both the PCOS patients and the controls in this study. Decreased levels of serum homocysteine, fasting insulin and homeostasis model assessment insulin resistance (HOMA-IR) levels were observed in CC and CT genotypes, but not in the TT group after treatment. Conclusion: It was observed in this study that the levels of cardiovascular risk factors like homocysteine, insulin, and HOMA-IR dropped in the patients who were administered oral contraceptives for 6 months.

Polycystic ovary syndrome, methylenetetrahydrofolate reductase polymorphism...


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