THIOL – DISULPHIDE HOMEOSTASIS AS A NOVEL OXIDATIVE STRESS MARKER IN PULMONARY THROMBOEMBOLISM

Abstract

Aim: Our aim of this study is to investigate how thiol/disulfide homeostasis changes in patients with
pulmonary thromboembolism (PTE).
Material and Methods: In our study, serum thiol/disulphide levels of 45 patients diagnosed with
PTE and 50 healthy controls were measured with a new automated spectrometric method and the
results were compared statistically.
Results: We found that the native thiol, total thiol, native thiol/total thiol levels were significantly
lower in the patient group than the control group, while the disulphide, disulphide/natural thiol,
disulphide/total thiol levels were significantly higher.
Conclusion: As a result of our study, we saw that the oxidant-antioxidant balance shifted in the
oxidative direction. The disulfide / native thiol ratio can be considered as an oxidative stress
parameter in PTE. We think that disruption of the thiol-disulfide balance may be important in the
pathogenesis of PTE.
Keywords: Pulmonary thromboembolism, thiol–disulphide homeostasis, oxidative stress.